2001; Neuge- bauer 2001; Varney and Gereau 2002). These newer-generation extended-spectrum cephalosporins managed to avoid hydrolysis by alterations in the β-lactam molecule that interfered with effective interaction with the β-lactamase, while still retaining their binding affinity to target PBPs.
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The conformationally restricted pyrrolidine derivatives immepyr (21) and SCH 50971 (22) support this phammcophore a evoked contTactions of guinea pig ileum (pD2 value).
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A conformational search of the active site geometry with the natural substrate, 7].
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